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KMID : 1103920120180040391
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Korean Journal of Hepatology
2012 Volume.18 No. 4 p.391 ~ p.396
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Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis: a multicenter retrospective study in Korea
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Kim Jin-Nyoung
Sohn Kyoung-Min
Kim Moon-Young
Suk Ki-Tae
Jeong Soung-Won
Jung Ho-Eun
Lee Sae-Hwan
Kim Sang-Gyune
Jang Jae-Young
Kim Young-Seok
Baik Soon-Koo
Kim Hong-Soo
Kim Dong-Joon
Kim Boo-Sung
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Abstract
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Background/Aims: Variceal hemorrhage is one of the major complications of cirrhosis and is associated with significant mortality and morbidity. The development of gastroesophageal varices and variceal hemorrhage is the most direct consequence of portal hypertension. Correlations between the hepatic venous pressure gradient (HVPG) and first variceal hemorrhage were examined.
Methods: Patients with cirrhosis who underwent HVPG measurement between July 2009 and September 2010 were enrolled (n=535). All patients underwent esophagogastroduodenoscopy to enable the evaluation of gastroesophageal varices.
Results: The HVPG for all patients was 16.46±7.05 mmHg (mean±SD), and was significantly higher among those with first variceal hemorrhage than in those without it. The HVPG was significantly correlated with both Child-Turcotte-Pugh (r=0.488, P<0.001) and Model for End-stage Liver Disease (r=0.478, P<0.001) scores. An HVPG value of 11 mmHg was predictive of first variceal hemorrhage with a sensitivity of 92.4% and a specificity of 27.7%.
Conclusions: The HVPG was higher in patients with first variceal hemorrhage than in those without it.
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KEYWORD
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Hepatic venous pressure gradient (HVPG), Variceal hemorrhage
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